Interchromosomal Translocations as a Means to Map Chromosome Territories in Breast Cancer
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چکیده
منابع مشابه
Intermingling of Chromosome Territories in Interphase Suggests Role in Translocations and Transcription-Dependent Associations
After mitosis, mammalian chromosomes partially decondense to occupy distinct territories in the cell nucleus. Current models propose that territories are separated by an interchromatin domain, rich in soluble nuclear machinery, where only rare interchromosomal interactions can occur via extended chromatin loops. In contrast, recent evidence for chromatin mobility and high frequency of chromosom...
متن کاملChromosome territories.
Chromosome territories (CTs) constitute a major feature of nuclear architecture. In a brief statement, the possible contribution of nuclear architecture studies to the field of epigenomics is considered, followed by a historical account of the CT concept and the final compelling experimental evidence of a territorial organization of chromosomes in all eukaryotes studied to date. Present knowled...
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ETEROZYGOUS autosomal translocations have been shown to affect recomHbination in the X chromosome in various ways (HINTON 1965); translocations with long interstitial distances increased recombination in X, those with short interstitial distances decreased recombination in X, and those with intermediate interstitial distances had little or no effect. Other incidental tests of translocation hete...
متن کاملChromosome translocations in workers exposed to benzene.
As benzene has been linked with elevated risk of both acute myeloid leukemia and lymphoma, we explored the effect of benzene exposure on levels of t(8;21), t(15;17), and t(14;18) translocations. Circulating lymphocytes of normal individuals also often contain t(14;18). Quantitative polymerase chain reaction analysis showed that 37 workers with benzene exposure had a decreased level of t(14;18) ...
متن کاملChromosome Territories Meet a Condensin
In human diploid cells, 23 pairs of chromosomes become recognizable as a discrete set of rod-shaped entities during the mitotic stage of the cell cycle. Upon exit from mitosis, they decondense and are packed together into the nucleus, in which individual chromosomes are no longer discernible. Nonetheless, evidence accumulated during past decades suggests that the decondensed chromosomes are not...
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ژورنال
عنوان ژورنال: Cancer Informatics
سال: 2019
ISSN: 1176-9351,1176-9351
DOI: 10.1177/1176935119842573